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1

[IEEE 2002 IEEE Aerospace Conference - Big Sky, MT, USA (9-16 March 2002)] Proceedings, IEEE Aerospace Conference - Mars Sample Return mission studies leading to a reduced-risk dual-lander mission using solar electric propulsion

Balmanno, W.F., Whiddon, W.B., Anderson, R.L.

Year:

2002

Language:

english

File:

PDF, 809 KB

english, 2002

2

Adaptation to chronic mTOR inhibition in cancer and in aging

Gilley, Rebecca, Balmanno, Kathryn, Cope, Claire L., Cook, Simon J.

Journal:

Biochemical Society Transactions

Year:

2013

Language:

english

File:

PDF, 327 KB

english, 2013

3

Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines

Kathryn Balmanno, Simon D. Chell, Annette S. Gillings, Shaista Hayat, Simon J. Cook

Journal:

International Journal of Cancer

Year:

2009

Language:

english

File:

PDF, 466 KB

english, 2009

4

1H NMR studies of human urine: Urinary elimination of the anticancer drug carboplatin

John D. Ranford, Peter J. Sadler, Katherine Balmanno, David R. Newell

Journal:

Magnetic Resonance in Chemistry

Year:

1991

Language:

english

File:

PDF, 383 KB

english, 1991

5

Pharmacokinetics and pharmacodynamics of prolonged oral etoposide in women with metastatic breast cancer

Michael J. Millward, David R. Newell, Kally Yuen, Jane P. Matthews, Kathryn Balmanno, Christopher J. Charlton, Lindsey Gumbrell, Michael J. Lind, Fiona Chapman, Madeleine Proctor, Dorothy Simmonds, Br

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1995

Language:

english

File:

PDF, 756 KB

english, 1995

6

Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics

Annette S. Gillings, Kathryn Balmanno, Ceri M. Wiggins, Mark Johnson, Simon J. Cook

Journal:

Year:

2009

Language:

english

File:

PDF, 308 KB

english, 2009

7

Phase II trial of trimelamol in refractory ovarian cancer

Judson, IR, Calvert, AH, Gore, ME, Balmanno, K, Gumbrell, LA, Perren, T, Wiltshaw, E

Journal:

British Journal of Cancer

Year:

1991

Language:

english

File:

PDF, 479 KB

english, 1991

8

Tumour cell survival signalling by the ERK1/2 pathway

Balmanno, K, Cook, S J

Journal:

Cell Death & Differentiation

Year:

2008

Language:

english

File:

PDF, 259 KB

english, 2008

9

Colorectal cancer cells with the BRAFV600E mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM

Wickenden, J A, Jin, H, Johnson, M, Gillings, A S, Newson, C, Austin, M, Chell, S D, Balmanno, K, Pritchard, C A, Cook, S J

Journal:

Year:

2008

Language:

english

File:

PDF, 317 KB

english, 2008

10

ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL

Ewings, Katherine E, Hadfield-Moorhouse, Kathryn, Wiggins, Ceri M, Wickenden, Julie A, Balmanno, Kathryn, Gilley, Rebecca, Degenhardt, Kurt, White, Eileen, Cook, Simon J

Journal:

The EMBO Journal

Year:

2007

Language:

english

File:

PDF, 329 KB

english, 2007

11

Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells

Balmanno, Kathryn, Cook, Simon J

Journal:

Year:

1999

Language:

english

File:

PDF, 355 KB

english, 1999

12

ΔMEKK3:ER* activation induces a p38α/β2-dependent cell cycle arrest at the G2 checkpoint

Garner, Andrew P, Weston, Claire R, Todd, Daniel E, Balmanno, Kathryn, Cook, Simon J

Journal:

Year:

2002

Language:

english

File:

PDF, 377 KB

english, 2002

13

Activation of ERK1/2 by ΔRaf-1 : ER* represses Bim expression independently of the JNK or PI3K pathways

Weston, Claire R, Balmanno, Kathryn, Chalmers, Claire, Hadfield, Kathryn, Molton, Sarah A, Ley, Rebecca, Wagner, Erwin F, Cook, Simon J

Journal:

Year:

2003

Language:

english

File:

PDF, 529 KB

english, 2003

14

ERK1/2 and p38 cooperate to induce a p21CIP1-dependent G1 cell cycle arrest

Todd, Daniel E, Densham, Ruth M, Molton, Sarah A, Balmanno, Kathryn, Newson, Catherine, Weston, Claire R, Garner, Andrew P, Scott, Linda, Cook, Simon J

Journal:

Year:

2004

Language:

english

File:

PDF, 525 KB

english, 2004

15

The conditional kinase ΔMEKK1:ER* selectively activates the JNK pathway and protects against serum withdrawal-induced cell death

Sarah A. Molton, Claire Weston, Kathryn Balmanno, Catherine Newson, Daniel E. Todd, Andrew P. Garner, Simon J. Cook

Journal:

Cellular Signalling

Year:

2005

Language:

english

File:

PDF, 612 KB

english, 2005

16

The duration of ERK1/2 activity determines the activation of c-Fos and Fra-1 and the composition and quantitative transcriptional output of AP-1

Claire J. Chalmers, Rebecca Gilley, Helen N. March, Kathryn Balmanno, Simon J. Cook

Journal:

Cellular Signalling

Year:

2007

Language:

english

File:

PDF, 1.02 MB

english, 2007

17

ERK1/2 and p38 cooperate to delay progression through G1 by promoting cyclin D1 protein turnover

Ruth M. Densham, Daniel E. Todd, Kathy Balmanno, Simon J. Cook

Journal:

Cellular Signalling

Year:

2008

Language:

english

File:

PDF, 1.36 MB

english, 2008

18

CDK1, not ERK1/2 or ERK5, is required for mitotic phosphorylation of BIMEL

Rebecca Gilley, Pamela A. Lochhead, Kathryn Balmanno, David Oxley, Jonathan Clark, Simon J. Cook

Journal:

Cellular Signalling

Year:

2012

Language:

english

File:

PDF, 1.16 MB

english, 2012

19

Regulation of MEK/ERK pathway output by subcellular localization of B-Raf

Andreadi, Catherine, Noble, Catherine, Patel, Bipin, Jin, Hong, Aguilar Hernandez, Maria M., Balmanno, Kathryn, Cook, Simon J., Pritchard, Catrin

Journal:

Biochemical Society Transactions

Year:

2012

Language:

english

File:

PDF, 358 KB

english, 2012

20

Phase I and pharmacokinetic study of a water-soluble etoposide prodrug, etoposide phosphate (BMY-40481)

M.J. Millward, D.R. Newell, V. Mummaneni, L.N. Igwemezie, K. Balmanno, C.J. Charlton, L. Gumbrell, M.J. Lind, F. Chapman, M. Proctor, D. Simmonds, B.M.J. Cantwell, G.A. Taylor, C. McDaniel, B. Winogra

Journal:

European Journal of Cancer

Year:

1995

Language:

english

File:

PDF, 352 KB

english, 1995

21

Tumour cell responses to new fibroblast growth factor receptor tyrosine kinase inhibitors and identification of a gatekeeper mutation in FGFR3 as a mechanism of acquired resistance

Chell, V, Balmanno, K, Little, A S, Wilson, M, Andrews, S, Blockley, L, Hampson, M, Gavine, P R, Cook, S J

Journal:

Year:

2013

Language:

english

File:

PDF, 2.16 MB

english, 2013

22

AN EXAMPLE OF UNIVERSAL HIRSUTENESS.

Squire, A.J.Balmanno

Journal:

Year:

1902

Language:

english

File:

PDF, 768 KB

english, 1902

23

AN INQUIRY INTO THE INFLUENCE OF PREGNANCY, THE PUERPERAL STATE, AND LACTATION ON THE DEVELOPMENT AND PROGRESS OF CHRONIC DISEASE OF THE SKIN

Squire, Balmanno

Journal:

Year:

1866

Language:

english

File:

PDF, 416 KB

english, 1866

24

ENELECTROLYSIS: AN IMPROVED METHOD OF OPERATING ON SUPERFLUOUS HAIRS

Squire, Balmanno

Journal:

Year:

1905

Language:

english

File:

PDF, 425 KB

english, 1905

25

Extracellular Signal-regulated Kinases 1/2 Are Serum-stimulated "BimEL Kinases" That Bind to the BH3-only Protein BimEL Causing Its Phosphorylation and Turnover

Ley, R., Ewings, K. E., Hadfield, K., Howes, E., Balmanno, K., Cook, S. J.

Journal:

Journal of Biological Chemistry

Year:

2004

Language:

english

File:

PDF, 1.03 MB

english, 2004

26

Raf-1:ER* Bypasses the Cyclic AMP Block of Extracellular Signal-Regulated Kinase 1 and 2 Activation but Not CDK2 Activation or Cell Cycle Reentry

Balmanno, K., Millar, T., McMahon, M., Cook, S. J.

Journal:

Molecular and Cellular Biology

Year:

2003

Language:

english

File:

PDF, 644 KB

english, 2003

27

Activation of the ERK1/2 Signaling Pathway Promotes Phosphorylation and Proteasome-dependent Degradation of the BH3-only Protein, Bim

Ley, R., Balmanno, K., Hadfield, K., Weston, C., Cook, S. J.

Journal:

Journal of Biological Chemistry

Year:

2003

Language:

english

File:

PDF, 725 KB

english, 2003

28

Amplification of the Driving Oncogene, KRAS or BRAF, Underpins Acquired Resistance to MEK1/2 Inhibitors in Colorectal Cancer Cells

Little, A. S., Balmanno, K., Sale, M. J., Newman, S., Dry, J. R., Hampson, M., Edwards, P. A. W., Smith, P. D., Cook, S. J.

Journal:

Science Signaling

Year:

2011

Language:

english

File:

PDF, 1.34 MB

english, 2011

29

Adaptation to mTOR kinase inhibitors by amplification of eIF4E to maintain cap-dependent translation

Cope, C. L., Gilley, R., Balmanno, K., Sale, M. J., Howarth, K. D., Hampson, M., Smith, P. D., Guichard, S. M., Cook, S. J.

Journal:

Journal of Cell Science

Year:

2014

Language:

english

File:

PDF, 2.40 MB

english, 2014

30

Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome

Ashford, Anne L., Dunkley, Tom P. J., Cockerill, Mark, Rowlinson, Rachel A., Baak, Lisa M., Gallo, Raffaella, Balmanno, Kathryn, Goodwin, Louise M., Ward, Richard A., Lochhead, Pamela A., Guichard, Sy

Journal:

Cellular and Molecular Life Sciences

Year:

2016

Language:

english

File:

PDF, 2.41 MB

english, 2016

31

Ascorbic Acid Economy in Surgical Patients as Indicated by Blood Ascorbic Acid Levels

Crandon, John H., Landau, Bernard, Mikal, Stanley, Balmanno, James, Jefferson, Mildred, Mahoney, Norman

Journal:

Boston Medical and Surgical Journal

Year:

1958

Language:

english

File:

PDF, 1.88 MB

english, 1958

32

RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence

Galloway, A., Saveliev, A., ukasiak, S., Hodson, D. J., Bolland, D., Balmanno, K., Ahlfors, H., Monzon-Casanova, E., Mannurita, S. C., Bell, L. S., Andrews, S., Diaz-Munoz, M. D., Cook, S. J., Corcor

Journal:

Year:

2016

Language:

english

File:

PDF, 1.17 MB

english, 2016

33

Copy of a Letter from the President of the Faculty of Physicians and Surgeons in Glasgow

Journal:

The Belfast Monthly Magazine

Year:

1813

Language:

english

File:

PDF, 403 KB

english, 1813

34

Regulation of Cell Cycle Re-entry by Growth, Survival & Stress Signalling Pathways

Cook, Simon J., Balmanno, Kathryn, Garner, Andrew, Millar, Tracy, Taverner, Claire, Todd, Daniel

Journal:

Biochemical Society Transactions

Year:

2000

Language:

english

File:

PDF, 138 KB

english, 2000

35

Thrombin inhibits Bim (Bcl-2-interacting mediator of cell death) expression and prevents serum-withdrawal-induced apoptosis via protease-activated receptor 1

CHALMERS, Claire J., BALMANNO, Kathryn, HADFIELD, Kathryn, LEY, Rebecca, COOK, Simon J.

Journal:

Biochemical Journal

Year:

2003

Language:

english

File:

PDF, 416 KB

english, 2003

36

Both MAP Kinase and PI3′-Kinase are required for cell cycle re-entry in quesicent CCI39 cells but MAPK is not required for asynchronous growth

Millar, Tracy, Balmanno, Kathryn, Cook, Simon

Journal:

Biochemical Society Transactions

Year:

1999

Language:

english

File:

PDF, 136 KB

english, 1999

37

Regulation of cell cycle re-entry by growth, survival and stress signalling pathways

Cook, S.J., Balmanno, K., Garner, A., Millar, T., Taverner, C., Todd, D.

Journal:

Biochemical Society Transactions

Year:

2000

Language:

english

File:

PDF, 703 KB

english, 2000

38

Tumour cell responses to MEK1/2 inhibitors: acquired resistance and pathway remodelling

Little, Annette S., Balmanno, Kathryn, Sale, Matthew J., Smith, Paul D., Cook, Simon J.

Journal:

Biochemical Society Transactions

Year:

2012

Language:

english

File:

PDF, 245 KB

english, 2012

39

The relationship between intrinsic thymidylate synthase expression and sensitivity to THYMITAQTM in human leukaemia and colorectal carcinoma cell lines

Estlin, EJ, Balmanno, K, Calvert, AH, Hall, AG, Lunec, J, Newell, DR, Pearson, ADJ, Taylor, GA

Journal:

British Journal of Cancer

Year:

1997

Language:

english

File:

PDF, 1.44 MB

english, 1997

40

157 ESTIMATION OF THE IN VITRO AND IN VIVO INHIBITORY EFFECTS OF ANTIFOLATES UPON THYMIDYLATE SYNTHASE (TS) IN WHOLE CELLS

Taylor, Gordon A, Jackman, Ann L, Balmanno, Kathy, Hilary Calvert, A

Journal:

Pediatric Research

Year:

1988

Language:

english

File:

PDF, 138 KB

english, 1988

41

16. Animal Parasite Diseases of the Skin

SQUIRE, BALMANNO

Journal:

The American Journal of the Medical Sciences

Year:

1866

File:

PDF, 239 KB

1866

42

ERK1/2 signalling protects against apoptosis following endoplasmic reticulum stress but cannot provide long-term protection against BAX/BAK-independent cell death

Darling, Nicola J., Balmanno, Kathryn, Cook, Simon J., Rishi, Arun

Journal:

Year:

2017

Language:

english

File:

PDF, 6.09 MB

english, 2017

43

Over-expressed, N-terminally truncated BRAF is detected in the nucleus of cells with nuclear phosphorylated MEK and ERK

Hey, Fiona, Andreadi, Catherine, Noble, Catherine, Patel, Bipin, Jin, Hong, Kamata, Tamihiro, Straatman, Kees, Luo, Jinli, Balmanno, Kathryn, Jones, David T.W., Collins, V. Peter, Cook, Simon J., Caun

Journal:

Year:

2018

Language:

english

File:

PDF, 2.48 MB

english, 2018

44

Carboplatin pharmacokinetics in children: the development of a pediatric dosing formula. The United Kingdom Children's Cancer Study Group.

Newell, D R, Pearson, A D, Balmanno, K, Price, L, Wyllie, R A, Keir, M, Calvert, A H, Lewis, I J, Pinkerton, C R, Stevens, M C

Journal:

Journal of Clinical Oncology

Year:

1993

File:

PDF, 884 KB

1993

45

MEK1/2 inhibitor withdrawal reverses acquired resistance driven by BRAFV600E amplification whereas KRASG13D amplification promotes EMT-chemoresistance

Sale, Matthew J., Balmanno, Kathryn, Saxena, Jayeta, Ozono, Eiko, Wojdyla, Katarzyna, McIntyre, Rebecca E., Gilley, Rebecca, Woroniuk, Anna, Howarth, Karen D., Hughes, Gareth, Dry, Jonathan R., Arends

Journal:

Nature Communications

Year:

2019

Language:

english

File:

PDF, 5.19 MB

english, 2019

46

Dual-Mechanism ERK1/2 Inhibitors Exploit a Distinct Binding Mode to Block Phosphorylation and Nuclear Accumulation of ERK1/2

Kidger, Andrew M., Munck, Joanne M., Saini, Harpreet K., Balmanno, Kathryn, Minihane, Emma, Courtin, Aurelie, Graham, Brent, O'Reilly, Marc, Odle, Richard, Cook, Simon J.

Journal:

Molecular Cancer Therapeutics

Year:

2020

File:

PDF, 2.67 MB

2020